South San Diego Vacations from $287

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Your South San Diego Vacation

Leave all the planning to us with a South San Diego vacation package. With everything arranged before you jet off, all you'll have to do is relax and enjoy this destination's wonders to the fullest. A trip to South San Diego wouldn't be complete without spending a day or two in Chula Vista. This city is among the leading places to visit here. From the moment you book your South San Diego vacation to when you get back home, Expedia will be with you every step of the way.

The Latest South San Diego vacation packages

Price found within the past 48 hours. Click for updated prices.
Hyland Inn Near Legoland
Park Hyatt Aviara Resort, Golf Club & Spa
Quiet Mind Mountain Lodge, Retreat and Spa
City24 Hotel Little Italy Mission Hills
Coronado Beach Resort
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Where to stay in South San Diego

Find the best South San Diego areas and neighborhoods for the activities you enjoy most. Learn more about South San Diego

Discover the most popular places to visit in South San Diego

What to do in South San Diego

South San Diego Hotel Deals

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $238 total per night from Jan 9 to Jan 10
$238 total
Jan 9 - Jan 10
Total with taxes and fees
8.2/10 Very Good! (3,237 reviews)
Spotless

Reviewed on Jan 6, 2026

Sheraton San Diego Resort
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $155 total per night from Jan 25 to Jan 26
$155 total
Jan 25 - Jan 26
Total with taxes and fees
9/10 Wonderful! (3,264 reviews)
Beautiful views from room 248! Great service throughout our stay from all the departments! Quiet, serenely quiet which we really enjoyed. Everything was clean, spacious, kept up and easy to navigate.

Reviewed on Jan 6, 2026

Bay Club Hotel & Marina
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St San Diego CA
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $157 total per night from Jan 19 to Jan 20
$157 total
Jan 19 - Jan 20
Total with taxes and fees
8.8/10 Excellent! (191 reviews)
I enjoyed the stay. Staff was pleasant just upset the ice machine didn’t work and could of used more towels

Reviewed on Jan 5, 2026

Courtyard by Marriott San Diego Downtown Little Italy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best South San Diego Vacation Packages

South San Diego Essential Information

Language
English
Currency
U.S dollars
Closest Airport
San Diego Intl. Airport (SAN)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.